期刊
GLYCOBIOLOGY
卷 28, 期 8, 页码 556-564出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/glycob/cwy027
关键词
KEAP1; NRF2; O-GlcNAc; oxidative stress
资金
- Rita Allen Foundation
- Sidney Kimmel Foundation
- Concern Foundation
- Mizutani Foundation
- National Institute of General Medical Sciences [1R01GM118847, 1R01GM117473]
- Duke Cancer Institute
- Department of Defense [W81XWH-12-1-0148, W81XWH-14-1-0309, W81XWH-15-1-0486]
- National Cancer Institute [1R01CA125618]
In metazoans, thousands of intracellular proteins are modified with O-linked beta-N-acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In particular, a complex and evolutionarily conserved interplay between O-GlcNAcylation and oxidative stress has emerged in recent years. Here, we review the current literature on the connections between O-GlcNAc and oxidative stress, with a particular emphasis on major signaling pathways, such as KEAP1/NRF2, FOXO, NF kappa B, p53 and cell metabolism. Taken together, this work sheds important light on the signaling functions of protein glycosylation and the mechanisms of stress responses alike and illuminates how the two are integrated in animal cell physiology.
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