期刊
GENOME BIOLOGY
卷 19, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13059-018-1503-4
关键词
Experimental evolution; Evolve and resequence; Thermal adaptation; Pool-Seq; RNASeq
资金
- Marie Sklodowska-Curie Individual Fellowship [H2020-MSCA-IF-661149]
- European Research Council (ERC) grant ArchAdapt
- Austrian Science Funds (FWF) [W1225]
Background: Population genetic theory predicts that rapid adaptation is largely driven by complex traits encoded by many loci of small effect Because large-effect loci are quickly fixed in natural populations, they should not contribute much to rapid adaptation. Results: To investigate the genetic architecture of thermal adaptation - a highly complex trait - we performed experimental evolution on a natural Drosophila simulans population. Transcriptome and respiration measurements reveal extensive metabolic rewiring after only approximately 60 generations in a hot environment. Analysis of genome-wide polymorphisms identifies two interacting selection targets, Sestrin and SNF4A gamma, pointing to AMPK, a central metabolic switch, as a key factor for thermal adaptation. Conclusions: Our results demonstrate that large-effect loci segregating at intermediate allele frequencies can allow natural populations to rapidly respond to selection. Because SNF4A gamma also exhibits clinal variation in various Drosophila species, we suggest that this large-effect polymorphism is maintained by temporal and spatial temperature variation in natural environments.
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