期刊
FEMS MICROBIOLOGY LETTERS
卷 365, 期 10, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fny084
关键词
alcohol toxicity; syngas; Clostridia; CO2 utilisation; IC50
类别
资金
- Generalitat de Catalunya (2013 FI-DGR)
- Spanish Ministry [CTQ2014-53718-R, CTM2013-43454-R]
- BOF fellowship [BOF15/PDO/068]
- Catalan Government [2017SGR-1552, 2017SGR-548]
Research efforts aimed at increasing ethanol and butanol productivity from syngas are currently gaining attention. For most model carboxydotrophic bacteria, production rates, yields and maximum product titres have been studied in detail, but little is known on alcohol toxicity in these bacteria. The aim of this work was to investigate the inhibitory effects of ethanol and butanol on the growth of Clostridium ljungdahlii PETC, C. carboxidiwrans P7, and 'Butyribacterium methylotrophicum DSM3468'. Experiments to determine inhibitory effects due to product accumulation were carried out using a synthetic mixture of CO:CO2:H-2 as a substrate. These conditions were chosen to mimic gaseous effluents of biomass and waste gasification plants. Inhibition effects were recorded as changes in growth parameters. No significant inhibition was observed for ethanol at concentrations below 15 g/L. The three species exhibited higher sensitivity to butanol. Half inhibition constants for butanol could be estimated for P7 (IC50 = 4.12 g/L), DSM3468 (IC50 = 1.79 g/L), and PETC IC50 = 9.75 g/L). In conclusion, at least for the tested strains, alcohol toxicity is not an immediate handicap for increasing alcohol production of the tested homoacetogenic strains.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据