期刊
FEMS MICROBIOLOGY LETTERS
卷 365, 期 12, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fny097
关键词
respiratory Complex I; enzyme stability; role of Ca2+
类别
资金
- Biocentrum Helsinki
- Sigrid Juselius Foundation
- Magnus Ehrnrooth foundation
Stability of the membrane-bound and purified H+-translocating NADH:ubiquinone oxidoreductase, Complex I, was studied. The loss of the enzyme activity is strongly increased by alkaline pH and dilution of the sample. Complex I inactivation is prevented specifically by a low concentration of Ca2+ and/or an intracellular stabilization factor (ISF). The action of both, Ca2+ and ISF, on Complex I stability is interdependent. The data are discussed in terms of a release of structural Ca2+-as a reason for Complex I decay and an effect of ISF on the affinity and/or accessibility of Ca2+-binding site.
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