期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 19, 期 -, 页码 5-14出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.pdpdt.2017.04.001
关键词
CuS nanoparticles; Photothermal; Photodynamic; Heating; Reactive oxygen species (ROS)
类别
资金
- National Key Research and Development Program of China [2016YFB0700800]
- National Natural Science Foundation of China [81271957]
- National Basic Research Program of China [2012CB619106]
- Guangdong Key Lab of Orthopedic Technology and Implant Materials Construction Grant [2011233-32]
- U.S. Army Medical Research Acquisition Activity (USAMRAA) [W81XWH-10-1-0279, W81XWH-10-1-0234]
- NSF
- DHS joint ARI program [2011-DN-077-ARI053-02, 2011-DN-077-ARI053-03, 2011-DN-077-ARI053-04, 2011-DN-077-ARI053-05]
- NATIONAL CANCER INSTITUTE [R15CA199020] Funding Source: NIH RePORTER
Photodynamic therapy (PDT) and photothermal therapy (PTT) have been emerging as attractive and promising methods for tumor treatment in clinical approaches. CuS nanoparticles are effective and cost-effective agents for PIT. Recently, it was observed that CuS nanoparticles are also excellence candidates for PDT. However, the mechanisms for CuS nanoparticles as PDT agents have never been discussed. The goal here is to explore the killing mechanisms of CuS nanoparticles as PTT and PDT agents. CuS nanoparticles were synthesized by a simple wet chemistry method by coating with amphiphilic polymer and examined for their therapeutic potential on lung adenocarcinoma cell line SPC-A-1 in vitro and in vivo using a murine cancer model. The CuS nanoparticles produce heat as well as reactive oxygen species (ROS) when excited by 808 nm laser and show strong anticancer effects both in vitro and in vivo. The heating effects and release of copper ions from CuS upon heating in the tumor acidic environments are the main mechanisms for the generation of reactive oxygen species which are lethal bullets for cancer destruction. As a dual-function agent for PTT and PDT, CuS nanoparticles are promising phototherapy agents for cancer treatment.
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