期刊
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
卷 43, 期 1, 页码 19-24出版社
ELSEVIER DOYMA SL
DOI: 10.1016/j.aller.2013.08.003
关键词
Anticonvulsants; Drug hypersensitivity; Eosinophilia
资金
- Dong-A University research fund
Background: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare disease which can cause severe morbidity and mortality. The aim of this study is to evaluate the clinical manifestation and course of DRESS syndrome. Methods: We conducted a retrospective analysis of prospectively collected data in 45 patients with DRESS syndrome diagnosed between September 2009 and August 2011. Results: The most common causative drug group was antibiotics (n = 13, 28.9%), followed by anticonvulsants (n = 12, 26.7%), antituberculosis drugs (n = 6, 13.3%), non-steroidal anti-inflammatory drugs (n = 4, 8.9%), undetermined agents (n = 4, 8.9%), allopurinol (n = 3, 6.7%), and others (n = 3, 6.7%). The latency period ranged from 2 to 120 days, with a mean of 20.2 +/- 24.3 days. The longest latency period was noted for the antituberculosis drug group, at 46.5 +/- 29.9 days. Eosinophilia in peripheral blood examination was noted in 35 subjects (77.8%). Atypical lymphocytosis was noted in 16 patients (35.6%), and thrombocytopenia in seven patients (15.6%). Hepatic involvement was noted in 39 (86.7%) study patients, kidney in eight (17.8%), Lung in four (8.9%), and central nervous system in one (2.3%). Systemic corticosteroids were administered to 10 patients (22.2%). Forty-three patients (95.6%) showed complete recovery, while two patients had poor outcomes. Conclusions: DRESS syndrome was not more uncommon than generally recognised. Antibiotics were the most frequently implicated drug group, followed by anticonvulsants. Most patients with this disease showed a better clinical outcome than that which had been generally expected. (C) 2013 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据