期刊
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
卷 33, 期 5, 页码 253-259出版社
WILEY
DOI: 10.1111/phpp.12312
关键词
acne; daylight; methyl aminolevulinate; nonablative fractional laser; phototherapy
类别
资金
- Galderma Research Development
BackgroundPhotodynamic therapy (PDT) has been reported as an effective alternative treatment for patients with acne. PurposeTo evaluate the efficacy and safety of DL-PDT in moderate to severe acne and to compare outcomes with those of laser-assisted daylight photodynamic therapy. MethodsPatients were randomly assigned to either a DL-PDT group (D group) or a fractional laser-assisted DL-PDT group (F group). The outcomes were assessed by measuring acne lesion counts and severity grade at 4, 8, 12, and 16weeks after therapy commenced. ResultsTwenty-eight subjects completed the study. Compared with baseline, the mean inflammatory lesion counts significantly decreased by 36.0% in the D group and 51.8% in the F group at 8weeks (P<.001). The mean acne severity grades in both groups significantly decreased starting at 4weeks (P=.012), and the beneficial effects lasted 16weeks. ConclusionDL-PDT with MAL shows clinically good responses to inflammatory lesions and is well tolerated in patients with moderate to severe acne.
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