4.6 Review

Activation of microbial secondary metabolic pathways: Avenues and challenges

期刊

SYNTHETIC AND SYSTEMS BIOTECHNOLOGY
卷 3, 期 3, 页码 163-178

出版社

KEAI PUBLISHING LTD
DOI: 10.1016/j.synbio.2018.09.001

关键词

Biosynthesis; Chemical diversity; Genome mining; Metabolic engineering; Synthetic biology

资金

  1. Jane and Aatos Erkko Foundation

向作者/读者索取更多资源

Microbial natural products are a tremendous source of new bioactive chemical entities for drug discovery. Next generation sequencing has revealed an unprecedented genomic potential for production of secondary metabolites by diverse micro-organisms found in the environment and in the microbiota. Genome mining has further led to the discovery of numerous uncharacterized 'cryptic' metabolic pathways in the classical producers of natural products such as Actinobacteria and fungi. These biosynthetic gene clusters may code for improved biologically active metabolites, but harnessing the full genetic potential has been hindered by the observation that many of the pathways are 'silent' under laboratory conditions. Here we provide an overview of the various biotechnological methodologies, which can be divided to pleiotropic, biosynthetic gene cluster specific, and targeted genome-wide approaches that have been developed for the awakening of microbial secondary metabolic pathways.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据