期刊
CURRENT OPINION IN BIOMEDICAL ENGINEERING
卷 7, 期 -, 页码 71-82出版社
ELSEVIER
DOI: 10.1016/j.cobme.2018.10.002
关键词
Cell penetrating peptide; DNA; Gene delivery; Non-viral vectors; Peptide
资金
- National Institute of Health (NIH)
- National Science Foundation (NSF) [NIH R01 AR067247, NIH R01 EB017766, NSF 1700980, NSF 1605130]
The diverse amino acid chemistries and secondary structures in peptides provide 'minimalist' mimics of motifs in proteins and offer many ideal properties for targeted delivery approaches. Several non-viral vectors (polymers and lipids) have been studied for their potential applications in gene delivery. However, non-specific uptake, lack of targeting, inability to escape endosomes, and inefficient nuclear delivery limit their application. Peptide-assisted trafficking of non-viral vectors can potentially overcome these biological barriers to improve gene delivery through targeted uptake using key cell-surface receptors (e.g., integrins, growth factor receptors, and G-protein coupled receptors); membrane disruption for endosomal escape; and nuclear importation. Furthermore, the capacity of peptides to regulate spatio-temporal control over gene delivery opens multi-faceted avenues for effective gene delivery in a variety of complex applications. Rigorous on-going in vitro and in vivo studies utilizing peptides for targeted and microenvironment-sensitive gene delivery could promote their widespread clinical usage.
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