期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 372, 期 1737, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2016.0488
关键词
extracellular vesicles; EV; cancer; intercellular communication; microenvironment
类别
资金
- BBSRC [BB/P000223/1]
- Biotechnology and Biological Sciences Research Council [BB/P000223/1] Funding Source: researchfish
- BBSRC [BB/P000223/1] Funding Source: UKRI
Extracellular vesicles (EVs) are small-membrane vesicles secreted by most cells types with the role to provide intercellular communication both locally and systemically. The transfer of their content between cells, which includes nucleic acids, proteins and lipids, confers the means for these interactions and induces significant cellular behaviour changes in the receiving cell. EVs are implicated in the regulation of numerous physiological and pathological processes, including development and neurological and cardiovascular diseases. Importantly, it has been shown that EV signalling is essential in almost all the steps necessary for the progress of carcinomas, from primary tumours to metastasis. In this review, we will focus on the latest findings for EV biology in relation to cancer progression and the tumour microenvironment. This article is part of the discussion meeting issue 'Extracellular vesicles and the tumour microenvironment'.
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