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Antimicrobial peptides: Role in human disease and potential as immunotherapies

期刊

PHARMACOLOGY & THERAPEUTICS
卷 178, 期 -, 页码 132-140

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2017.04.002

关键词

Antimicrobial peptides (AMPs); Synthetic peptides; Antibiotic resistance; Immune modulation; Infectious diseases; Inflammation; Vitamin D; Host-directed therapy

资金

  1. Fundacao para a Ciencia e a Tecnologia - Ministerio da Ciencia, Tecnologia
  2. CNPq
  3. CAPES
  4. FADPDF
  5. FINEP
  6. FUNDECT
  7. Ramon Areces Foundation (Spain)
  8. National Council of Technological and Scientific Development (CNPq)
  9. Fundacao Apoio ao Desenvolvimento do Ensino, Ciencia e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT) [300583/2016-8]
  10. National Institutes of Health [1P50GM098792, 1R21AI12166901]
  11. National Science Foundation [MCB-1350625]
  12. Defense Threat Reduction Agency [HDTRA1-14-1-0007, HDTRA1-15-1-0050]
  13. Defense Advanced Research Projects Agency
  14. Office of Naval Research
  15. Army Research Office
  16. Center for Microbiome Informatics and Therapeutics
  17. Broad Institute of MIT and Harvard
  18. Koch Institute for Integrative Cancer Research
  19. Kuwait-MIT Center for Natural Resources and Environment

向作者/读者索取更多资源

Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate immune system. These agents are produced by various cells throughout the human body and play important roles in our ability to respond to infections. In this review, we outline evidence linking AMP expression with a range of inflammatory and autoimmune human diseases. Finally, we highlight the promise of endogenous AMP induction for the treatment of disease (i.e., host-directed therapy) and briefly mention the different peptide drugs that are currently undergoing clinical trials. (C) 2017 Elsevier Inc. All rights reserved.

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