期刊
PHARMACOLOGY
卷 100, 期 5-6, 页码 292-300出版社
KARGER
DOI: 10.1159/000479879
关键词
Carnosine; Sepsis; Malondialdehyde; Superoxide dismutase; Catalase; Inflammation
This study analyzes the sepsis healing therapeutic potential of carnosine against experimentally sepsis-induced male albino rats. Carnosine in 2 different doses, 25 mg/kg and 50 mg/kg, were administered for 30 consecutive days. At the end of the treatment, lipid peroxidation, catalase, superoxide dismutase, glutathione peroxidase and myeloperoxidase activities were measured. Lungs weight and total protein content were determined in the bronchoalveolar fluid (BALF). Cytokines such as macrophage inhibitory factor (MIF), interleukin-8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) were determined in the BALF. In addition, the histopathological analysis was also carried out to understand the effect of carnosine in the cellular architecture. Carnosine treatment significantly renormalized the lipid peroxidation and other antioxidant enzymes. IL-beta, TNF-alpha, and MIF were found to be reduced after carnosine treatment. After carnosine treatment, the intensity of sepsis was significantly reduced evidenced by histopathological analysis. In western blot analysis, carnosine treatment causes the upregulation of I kappa B alpha together with the downregulation of the expressions of p65 and p-IKK alpha/beta (Ser 180/Ser 181). (C) 2017 S. Karger AG, Basel
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