期刊
PHARMACOGENOMICS
卷 18, 期 10, 页码 931-943出版社
FUTURE MEDICINE LTD
DOI: 10.2217/pgs-2017-0035
关键词
asthma; children; consortium; genetics; pharmacogenomics; treatment
资金
- Stichting Astma Bestrijding (SAB) [2014/063]
- ERA-Net ERACoSysMed [SysPharmPedia 99]
- Instituto de Salud Carlos III within the ERACoSysMed 1st Joint Transnational Call from the European Union [SysPharmPedia 99, AC15/00015]
- US NIH [HL079966, HL117191]
- UK Department of Heath Chair of Pharmaco-genetics
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Stockholm County Council (ALF)
- Strategic Research Programme (SFO) in Epidemiology at Karolinska Institutet
- Zon MW research grant [113201006]
- Chief Scientist Office [CZH/4/418] Funding Source: researchfish
- Lundbeck Foundation [R163-2013-16235] Funding Source: researchfish
- Medical Research Council [MR/L006758/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10064, NF-SI-0510-10075, CL-2006-07-002] Funding Source: researchfish
- MRC [MR/L006758/1] Funding Source: UKRI
Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. Materials & methods: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. Results: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium. Fifty six percent of the patients are Caucasians. In total, 7619 were inhaled corticosteroid users. Among patients from 13 studies with available data on asthma exacerbations, a third reported exacerbations despite inhaled corticosteroid use. In the future pharmacogenomics studies within the consortium, the pharmacogenomics analyses will be performed separately in each center and the results will be meta-analyzed. Conclusion: PiCA is a valuable platform to perform pharmacogenetics studies within a multiethnic pediatric asthma population.
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