期刊
PHARMACEUTICAL RESEARCH
卷 34, 期 11, 页码 2223-2240出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11095-017-2223-2
关键词
antigen stability; dissolving microneedle fabrication; dissolving microneedle characterization; skin immunization; vaccine delivery
资金
- Intravacc
The dermal route is an attractive route for vaccine delivery due to the easy skin accessibility and a dense network of immune cells in the skin. The development of microneedles is crucial to take advantage of the skin immunization and simultaneously to overcome problems related to vaccination by conventional needles (e.g. pain, needle-stick injuries or needle re-use). This review focuses on dissolving microneedles that after penetration into the skin dissolve releasing the encapsulated antigen. The microneedle patch fabrication techniques and their challenges are discussed as well as the microneedle characterization methods and antigen stability aspects. The immunogenicity of antigens formulated in dissolving microneedles are addressed. Finally, the early clinical development is discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据