期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 51, 期 6, 页码 456-464出版社
SPRINGER
DOI: 10.1007/s11094-017-1633-0
关键词
deoxyvasicinone; mackinazolinone; condensation; aromatic aldehydes; Vilsmeier-Haack reaction; nucleophilic substitution; arylidene, arylhydroxymethyl, and arylaminomethylidene derivatives; anti-microbial activity
Series of arylidene- and arylhydroxymethyl derivatives of 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-one and 2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-one were synthesized. Schiff bases were synthesized from amine derivatives. Hydroxymethylidene derivatives and arylaminomethylidene-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-9-ones and -2,3,4,10-tetrahydro-1H-pyrido[2,1-b]quinazolin-10-ones were obtained. The antimicrobial activity of the synthesized compounds against S. aureus, E. coli, Bacillus cereus, Candida albicans, and Pseudomonas aeruginosa was studied. It was concluded that the search for bactericides in these series was promising.
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