期刊
PHARMACEUTICAL CHEMISTRY JOURNAL
卷 51, 期 1, 页码 13-17出版社
SPRINGER
DOI: 10.1007/s11094-017-1548-9
关键词
adamantine; ethylcarbamate; virus infections; antiviral activity
资金
- Russian Ministry of Education and Science [4.1440.2014/K]
- Russian Foundation for Basic Research [15-43-02536]
The new adamantine derivative ethyl(3-ethyladamant-1-yl)carbamate was found to have high antiviral activity against herpes simplex virus and vaccinia viruses, as well as adenovirus (EC50 = 0.62, 5.15, and 48.5 mu g/ml respectively). Activity against the herpesvirus was demonstrated in experiments in various cell cultures using different virus strains, including a variant resistant to acycloguanosine (ACG). Simultaneous application of ethyl(3-ethyladamant-1-yl)carbamate and ACG increased the inhibition of herpesvirus reproduction in cell cultures and decreased the mortality of laboratory animals with experimental herpesvirus neuroinfection as compared with the use of each substance alone. 3-Ethyladamant-1-yl)carbamate was a low-toxicity compound, did not inhibit DNAsynthesis in uninfected cell cultures, and its acute intragastric LD50 for white mice was 1831.8 mg/kg.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据