期刊
PHARMACEUTICAL BIOLOGY
卷 55, 期 1, 页码 2153-2160出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880209.2017.1383486
关键词
Salvia przewalskii total phenolic acid extract; rosmarinic acid; salvianolic acid B; proteinuria; therapeutic efficacy
资金
- National Natural Science Foundation of China [81325024]
- National Specific Projects of New Drug Innovation of China [2009ZX09102-134]
- Medical Scientific and Technical Innovation Foundation Projects of Nanjing Military Command Region of CPLA [12MA027]
Context:Salvia przewalskii Maxim. (Lamiaceae) is a Chinese herbal medicine that has long been used for the treatment of cardiovascular disease. Objective: The study investigated the therapeutic efficacy of S. przewalskii total phenolic acid extract (SPE) on immune complex glomerulonephritis (ICG) in rats. Materials and methods: Sixty-two Wistar rats were randomized into six groups. ICG was induced in all groups except normal control group. SPE was administered intragastrically at 24h intervals for 40 consecutive days. Urine protein (UP), total serum protein (TSP), serum albumin (SA), serum cholesterol (SC) and serum urea nitrogen (SUN) were measured one day before, on day 20 and 40 after SPE administration. On day 40 after SPE administration, the kidneys were removed and prepared into pathologic sections. In addition, kidney wet mass was measured for calculating the kidney wet mass coefficient (KWMC). Results: UP excretion was reduced significantly on day 20 after SPE administration in all three SPE groups as compared with that in medium group, and this effect was observable continuously until 40days after SPE administration. Compared with medium group, TSP and SA were increased in all three SPE groups after 40days treatment, while SC and SUN were decreased. KWMC was decreased significantly in 100mg/kg SPE group after 40days treatment compared with that in medium group. Histopathologic analyses showed that renal inflammatory infiltration and kidney intumesce were alleviated in all three SPE groups. Conclusions: SPE may be a potential therapeutic drug for glomerulonephritis.
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