期刊
PEPTIDES
卷 87, 期 -, 页码 34-40出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.peptides.2016.11.008
关键词
Antibody; Centruroides limpidus; Scorpion venom; toxinToxin
资金
- grant Atencion a Problemas Nacionales CONACYT [PN-246924]
A previously undescribed toxic peptide named Cl13 was purified from the venom of the Mexican scorpion Centruroides limpidus. It contains 66 amino acid residues, including four disulfide bonds. The physiological effects assayed in 7 different subtypes of voltage gated Ne-channels, showed that it belongs to the beta-scorpion toxin type. The most notorious effects were observed in subtypes Nav1.4, Nav1.5 and Nav1.6. Although having important sequence similarities with two other lethal toxins from this scorpion species (Cll1m and Cll2), the recently developed single chain antibody fragments (scFv) of human origin were not capable of protecting against Cl13. At the amino acid sequence level, in 3 stretches of peptide Cl13 (positions 7-9, 30-38 and 62-66) some differences with respect to other similar toxins are observed. Some of these differences coincide with contact points with the human antibody fragments. (C) 2016 Elsevier Inc. All rights reserved.
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