期刊
CEREBRAL CORTEX
卷 28, 期 9, 页码 3309-3321出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx201
关键词
hippocampus; memory; miR-181a; mTOR
资金
- National Natural Science Foundation of China [31571321, 31171428, 31571100, 91432306, 31401219]
- Shandong Province Natural Science Foundation [ZR2014CM036, ZR2014CQ023]
- National Key Research and Development Program of China [2016YFE0129200]
- Fundamental Research Funds of Shandong University [2015JC036]
Long-term memory formation has been proven to require gene expression and new protein synthesis. MicroRNAs (miRNAs), as an endogenous small non-coding RNAs, inhibit the expression of their mRNA targets, through which involve in new memory formation. In this study, elevated miR-181a levels were found to be responsible for hippocampal contextual fear memory consolidation. Using a luciferase reporter assay, we indicated that miR-181a targets 2 upstream molecules of mTOR pathway, namely, PRKAA1 and REDD1. Upregulated miR-181a can downregulate the PRKAA1 and REDD1 protein levels and promote mTOR activity to facilitate hippocampal fear memory consolidation. These results indicate that miR-181a is involved in hippocampal contextual fear memory by activating the mTOR signaling pathway. This work provides a novel evidence for the role of miRNAs in memory formation and demonstrates the implication of mTOR signaling pathway in miRNA processing in the adult brain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据