期刊
PEDIATRIC RESEARCH
卷 81, 期 5, 页码 722-730出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2017.12
关键词
-
类别
资金
- Institute de Salud Carlos III (ISCIII)
- FEDER funds [PI12/00934, IC114/00282]
- Sociedad Espanola de Inmunologia Clinics, Alergologia y Asma Pedicitrica (SEI-CAP)
- ISCIII [CPII13/00033]
- Spanish MICINN [RYC-2009-05486]
- IISGM pre-doctoral grant
- FPU PhD Grant from the Ministerio de Educacion, Cultura y Deporte (Spain) [AP2012-2343]
BACKGROUND: Cow's milk protein allergy (CMPA) is the most common food allergy in infants. However, little is known about which specific immune mechanisms are related with the CMPA onset. The objective was to investigate which immune alterations constitute differential factors between allergy and tolerance, and hence could be implicated in the CMPA establishment in infants. METHODS: An extensive analysis of immune subsets, including Treg and cytokine-secreting cells was performed in blood samples from 28 infants younger than 9 mo obtained 1-4 d after the first adverse reaction to milk. RESULTS: Less than 4 d after first allergic reaction, infants who developed CMPA had decreased Treg counts and increased frequency of IL4-secreting CD4 T cells compared to controls. The deficit of Tregs was correlated with decreased serum levels of vitamin D. Values of Tregs, IL4-secreting cells and vitamin D were good predictors of CMPA diagnosis. Basal vitamin D levels in CMPA infants also predicted those CMPA patients developing spontaneous tolerance in the first year. CONCLUSION: Establishment of CMPA in infants was related with lower Treg and vitamin D levels. These immune alterations would be crucial factors behind the CMPA establishment and they could constitute a therapeutic target for treatment of CMPA.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据