期刊
VACCINES
卷 6, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/vaccines6030036
关键词
universal influenza vaccine; sialylation; Fc glycan; afucosylation; Fc receptors
资金
- Stanford School of Medicine
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [1K22AI12347801]
- Bill & Melinda Gates Foundation [OPP1113682-NA, OPP118846]
- Searle Scholars Program
- Chan Zuckerberg Biohub
Recent studies have revealed multiple roles for Fc gamma receptors (Fc gamma Rs) in broad immunity against influenza viruses. Activating Fc gamma R pathways can be harnessed to confer protection mediated by non-neutralizing anti-HA IgGs and to increase the potency of broadly neutralizing anti-HA IgGs and of anti-NA IgGs. Separate Fc gamma R pathways can be targeted to enhance the breadth of antibody responses elicited by seasonal influenza virus vaccines. Here, we review the current understanding of Fc gamma R pathways in broad influenza immunity and suggest mechanisms to bypass Fc gamma R signaling heterogeneity among people that arises from distinctions in structural repertoires of IgG Fc domains.
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