期刊
PEDIATRIC BLOOD & CANCER
卷 64, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/pbc.26451
关键词
intraspinal extension; late effects; long-term health problems; neuroblastoma; spinal cord compression; systematic review
资金
- Stichting Kinderen Kankervrij (KiKa) (Children Cancer Free Foundation)
- Zeldzame Ziekte Fonds (Rare Disease Fund)
We performed a systematic review to define the long-term health problems and optimal treatment strategy for patients with neuroblastoma with intraspinal extension. Of 685 identified studies, 28 were included in this review. The burden of long-term health problems is high; a median of 50% of patients suffered from neurological motor deficit, 34% from sphincter dysfunction, and 30% from spinal deformity. The currently available literature remains suboptimal as a guide for treatment of NBL with intraspinal extension. More well-designed, prospective studies are needed to determine the optimal treatment strategy.
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