期刊
EMERGING INFECTIOUS DISEASES
卷 24, 期 10, 页码 1882-1888出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid2410.161258
关键词
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资金
- National Institute of Allergy and Infectious Diseases, National Institutes of Health [U01AI088654, HHSN272201 400006C]
- Research Grants Council of the Hong Kong Special Administrative Region, China [T11-705/14N]
- Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences [U54 GM088558]
- John E. Fogarty International Center, National Institutes of Health [K02 TW009483]
During August 2012-November 2014, we conducted a case ascertainment study to investigate household transmission of influenza virus in Managua, Nicaragua. We collected up to 5 respiratory swab samples from each of 536 household contacts of 133 influenza virus-infected persons and assessed for evidence of influenza virus transmission. The overall risk for influenza virus infection of household contacts was 15.7% (95% CI 12.7%-19.0%). Oseltamivir treatment of index patients did not appear to reduce household transmission. The mean serial interval for within-household transmission was 3.1 (95% CI 1.6-8.4) days. We found the transmissibility of influenza B virus to be higher than that of influenza A virus among children. Compared with households with <4 household contacts, those with >= 4 household contacts appeared to have a reduced risk for infection. Further research is needed to model household influenza virus transmission and design interventions for these settings.
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