期刊
PATHOLOGY RESEARCH AND PRACTICE
卷 213, 期 7, 页码 730-736出版社
ELSEVIER GMBH
DOI: 10.1016/j.prp.2017.02.020
关键词
Gastric cancer; Tumor microenvironment; Cancer associated fibroblasts; MicroRNAs
类别
资金
- Shanghai Municipal Commission of Health and Family Planning [20154Y0145]
Cancer associated fibroblasts (CAFs) are a key component of the tumor microenvironment (TME). They play critical roles in the occurrence and development of gastric cancer (GC) through controlling various cytokines secretion and direct cell-to-cell interaction. However, the underlying mechanism of CAFs in tumor progression has not been entirely elucidated. MicroRNAs (miRNAs) as important factors have a central role in the interplay between tumor cell and TME. Recent studies also highlight that the aberrant expression of miRNAs in CAFs is involved in multiple functions in tumorigenesis and malignant process of GC. In this article, we shortly introduce the miRNAs biogenesis and provide an overview of the mechanisms and emerging roles of CAFs-related miRNAs. Focusing on these miRNAs as potential therapeutic targets may bring better treatment effect on GC and other diseases. (C) 2017 Elsevier GmbH. All rights reserved.
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