PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation

We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer. Here we place these findings in context with the role of inflammasomes in colorectal carcinoma, and with a recent study indicating that PTPN2-silencing promotes anti-cancer immunotherapy.