期刊
SCIENCE
卷 361, 期 6409, 页码 1332-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat8950
关键词
-
资金
- Ligue Nationale contre le Cancer (Equipe labelisee Ligue) [ANR-11-LABX-0044_DEEP, ANR-10-IDEX-0001-02 PSL, ANR-12-BSV5-0022-02, ANR-14-CE16-0009, ANR-14-CE10-0013]
- EU [678563 EPOCH28, ERC-2015-ADG-694694 ChromADICT, ANR-16-CE15-0018 CHRODYT, ANR-16-CE12-0024 CHIFT, ANR-16-CE11-0028 REPLICAF]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE10-0013] Funding Source: Agence Nationale de la Recherche (ANR)
During development and throughout life, a variety of specialized cells must be generated to ensure the proper function of each tissue and organ. Chromatin plays a key role in determining cellular state, whether totipotent, pluripotent, multipotent, or differentiated. We highlight chromatin dynamics involved in the generation of pluripotent stem cells as well as their influence on cell fate decision and reprogramming. We focus on the capacity of histone variants, chaperones, modifications, and heterochromatin factors to influence cell identity and its plasticity. Recent technological advances have provided tools to elucidate the underlying chromatin dynamics for a better understanding of normal development and pathological conditions, with avenues for potential therapeutic application.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据