期刊
JOURNAL OF ORTHOPAEDICS
卷 15, 期 3, 页码 854-857出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jor.2018.08.021
关键词
Perivascular stem cell; PSC; Wnt signaling; Osteogenesis; WNT3A; DKK1
类别
资金
- NIH/NIAMS [R01 AR070773, K08 AR068316]
- NIH/NIDCR [R21 DE027922]
- Department of Defense [W81XWH-18-1-0121, W81XWH-18-1-0336]
- American Cancer Society [RSG-18-027-01-CSM]
- Maryland Stem Cell Research Foundation
- Musculoskeletal Transplant Foundatio
Perivascular stem cells (PSC) are a progenitor population defined by their perivascular residence. Recent studies have examined the relative difference in Wnt ligands to induce PSC differentiation, including Wnt16. Here, we examine the role of Wnt16 in the proliferation and osteogenic differentiation of human PSC. Treatment of PSC with WNT16 significantly increased cell proliferation to a greater extent than did WNT3A. In addition, WNT16 showed a significant increase in osteogenic gene expression among PSC. These data demonstrate that WNT16 represents a combined mitogenic/pro-osteogenic stimulus that may play a functional role in human mesenchymal stem cell mediated bone repair.
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