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Mechanistic understanding of nanoparticles' interactions with extracellular matrix: the cell and immune system

期刊

PARTICLE AND FIBRE TOXICOLOGY
卷 14, 期 -, 页码 -

出版社

BMC
DOI: 10.1186/s12989-017-0199-z

关键词

Extracellular matrix; Nanoparticle; Inflammation; Biological barriers

资金

  1. ERA.NET RUS Plus program [169 - NABUCO]
  2. Russian Science Foundation [15-14-20032]
  3. COST Action [TD1204 MODENA]
  4. Russian Science Foundation [15-14-20032] Funding Source: Russian Science Foundation

向作者/读者索取更多资源

Extracellular matrix (ECM) is an extraordinarily complex and unique meshwork composed of structural proteins and glycosaminoglycans. The ECM provides essential physical scaffolding for the cellular constituents, as well as contributes to crucial biochemical signaling. Importantly, ECM is an indispensable part of all biological barriers and substantially modulates the interchange of the nanotechnology products through these barriers. The interactions of the ECM with nanoparticles (NPs) depend on the morphological characteristics of intercellular matrix and on the physical characteristics of the NPs and may be either deleterious or beneficial. Importantly, an altered expression of ECM molecules ultimately affects all biological processes including inflammation. This review critically discusses the specific behavior of NPs that are within the ECM domain, and passing through the biological barriers. Furthermore, regenerative and toxicological aspects of nanomaterials are debated in terms of the immune cells-NPs interactions.

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