期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 3, 期 5, 页码 675-689出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2018.07.008
关键词
ankyrin; arrhythmia; cytoskeleton; heart failure; ion channel; Na-v 1.5
资金
- Ohio State JB Project
- Healing Hearts of Central Ohio
- NIH [HL135754, HL134824, HL139348, HL135096, HL114383, HL135437, HL114893, HL137331]
Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal. compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure. Mechanistically, the authors illustrate that ankyrin-G serves as a key nodal protein required for cardiac myofilament integration with the intercalated disc. Their data define novel in vivo mechanistic roles for ankyrin-G, implicate ankyrin-G as necessary for compensatory cardiac physiological remodeling under stress, and implicate disruption of ankyrin-G in the development and progression of human heart failure. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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