期刊
METABOLITES
卷 8, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/metabo8030052
关键词
metabolomics; direct mass spectrometry; Alzheimer's disease; pathogenesis; biomarkers
资金
- University of Barcelona
Direct mass spectrometry-based metabolomics has been widely employed in recent years to characterize the metabolic alterations underlying Alzheimer's disease development and progression. This high-throughput approach presents great potential for fast and simultaneous fingerprinting of a vast number of metabolites, which can be applied to multiple biological matrices including serum/plasma, urine, cerebrospinal fluid and tissues. In this review article, we present the main advantages and drawbacks of metabolomics based on direct mass spectrometry compared with conventional analytical techniques, and provide a comprehensive revision of the literature on the use of these tools in the investigation of Alzheimer's disease.
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