期刊
PARASITE IMMUNOLOGY
卷 39, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/pim.12404
关键词
helminths; human; hygiene hypothesis; insulin resistance; metabolic disease; type 2 diabetes
资金
- Royal Netherlands Academy of Arts and Sciences [57-SPIN3-JRP]
- Universitas Indonesia [BOPTN 2742/H2.R12/HKP.05.00/2013]
- Indonesian Directorate General of Higher Education (DIKTI)
Worldwide, there is little overlap between the prevalence of soil-transmitted helminths and type 2 diabetes (T2D). Helminth-induced type 2 immune responses and immune regulatory network might modulate the obesity-induced activation of inflammatory pathways that are associated with the development of insulin resistance, a strong predictor of the development of T2D. However, other factors such as helminth-associated changes in adiposity and gut microbiome might also contribute to improved metabolic outcomes. In this review, we summarize epidemiological evidence for the link between helminths and T2D and discuss the potential mechanisms, based on findings from experimental studies as well as the limited number of studies in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据