Epigenetics in Cardiac Fibrosis Emphasis on Inflammation and Fibroblast Activation

Chemical modifications to nucleosomal DNA and histone tails greatly influence transcription of adjacent and distant genes, a mode of gene regulation referred to as epigenetic control. Here, the authors summarize recent findings that have illustrated crucial roles for epigenetic regulatory enzymes and reader proteins in the control of cardiac fibrosis. Particular emphasis is placed on epigenetic regulation of stress-induced inflammation and fibroblast activation in the heart. The potential of developing innovative small molecule epigenetic therapies to combat cardiac fibrosis is highlighted. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.