期刊
BIOMEDICAL REPORTS
卷 9, 期 2, 页码 147-155出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/br.2018.1113
关键词
microRNA-124-3p; gastric cancer; invasion; metastasis
资金
- Science and Technology Department of Hunan Province, China [2018JJ6071]
- Education Department of Hunan Province, China [16C1426]
- Science and Technology Department of Hengyang, China [2015KJ16]
miR-124-3p has been implicated in a variety of cancers. The purpose of the present study was to investigate the expression, prognostic roles and functions of miR-124-3p in gastric cancer. Functional studies indicated that ectopic overexpression of miR-124-3p in gastric cancer cells suppressed cell viability and plate colony formation in vitro and tumor growth in vivo. In situ hybridization analysis demonstrated that decreased expression of miR-124-3p was associated with clinical stage and lymph node metastasis, as well as shorter overall survival and disease-free survival rates. Furthermore, it was observed that miR-124-3p repressed the carcinogenesis of gastric cancer by targeting Ras-related C3 botulinum toxin substrate 1 (Rac1) and specificity protein 1 (SP1). Collectively, these results indicate a potential underlying mechanism for the regulation of gastric cancer by miR-124-3p involving targeting of Rac1 and SP1. Thus, miR-124-3p may be an independent indicator of survival and treatment strategy for patients with gastric cancer.
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