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Systematic review with meta-analysis: self-expanding metal stents in patients with cirrhosis and severe or refractory oesophageal variceal bleeding

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ALIMENTARY PHARMACOLOGY & THERAPEUTICS
卷 42, 期 11-12, 页码 1250-1260

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WILEY
DOI: 10.1111/apt.13424

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BackgroundThe prognosis of patients with cirrhosis and acute variceal bleeding is very poor when the standard-of-care fails to control bleeding. New treatment modalities are needed in these patients. AimTo synthesise the available evidence on the efficacy of self-expanding metal stents (SEMS) in patients with cirrhosis and severe or refractory oesophageal variceal bleeding. MethodsMeta-analysis of trials evaluating SEMS in patients with cirrhosis and severe or refractory oesophageal variceal bleeding. ResultsThirteen studies were included. The pooled estimate rates were 0.40 (95% confidence interval, CI=0.31-0.49) for death, 0.41 (95% CI=0.29-0.53) for liver-related death and 0.36 (95% CI=0.26-0.47) for death at day 30, with low heterogeneity between studies. The pooled estimate rates were 0.12 (95% CI=0.07-0.21) for mortality related to variceal bleeding, and 0.18 (95% CI=0.11-0.29) for failure to control bleeding with SEMS, with no or low heterogeneity between studies. The pooled estimate rate were 0.16 (95% CI=0.04-0.48) for rebleeding after stent removal and 0.28 (95% CI=0.17-0.43) for stent migration, with high heterogeneity. A significant proportion of patients had access to liver transplantation or to TIPSS [pooled estimate rate 0.10 (95% CI=0.04-0.21) and 0.26 (95% CI=0.18-0.36), respectively]. ConclusionsFewer than 40% of patients treated with SEMS were dead at 1month. SEMS can be used as a bridge to TIPSS or to liver transplantation in a significant proportion of patients. Additional studies are required to identify potential risk factors leading to a poor prognosis in patients with acute variceal bleeding in whom the use of SEMS could be considered.

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