期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 5, 期 5, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2015.1023929
关键词
intercellular DNA transfer; mitochondrial DNA deletion; metastasis; respiration; tumor growth
类别
资金
- Malaghan Institute
- Australian Research Council
- Czech Science Foundation [P301/10/1937]
- BIOCEV European Regional Development Fund [CZ.1.05/1.1.00/02.0109]
Horizontal gene transfer is known to occur in bacteria and archaea whereas higher organisms including mammals undergo vertical transfer. Our recent results demonstrate horizontal transfer of mitochondrial DNA (mtDNA) from normal host cells to tumor cells lacking mitochondrial DNA (mtDNA). This mtDNA migration results in recovery of respiration, restored tumor initiation, and metastasis.
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