期刊
MOLECULAR & CELLULAR ONCOLOGY
卷 5, 期 5, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/23723556.2018.1511208
关键词
double-strand break; Exo1; MRX; resection; S. cerevisiae
类别
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC) under IG grant [19783]
- Progetti di Ricerca di Interesse Nazionale (PRIN) 2015
Homologous recombination is initiated by nucleolytic degradation (resection) of DNA double-strand breaks (DSBs), which involves different nucleases including the Mre11-Rad50-Xrs2 (MRX) complex and the Exonuclease 1 (Exo1). The characterization of a novel mutation in Mre11 causing accelerated DSB resection has allowed to show that MRX facilitates DNA end processing by Exo1 through local unwinding of double-stranded DNA ends.
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