期刊
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
卷 50, 期 1, 页码 83-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.otc.2016.08.007
关键词
Aspirin-exacerbated respiratory disease; Chronic rhinosinusitis; Nasal polyposis; Sinus surgery
Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of aspirin. Patients with AERD have high rates of recidivistic polyposis following sinus surgery, although the improvement in quality of life following surgery is similar to aspirin-tolerant patients. The diagnosis is secured by a positive aspirin provocation test, usually administered by a medical allergist. Aspirin therapy is a unique treatment consideration for patients with AERD.
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