期刊
OSTEOARTHRITIS AND CARTILAGE
卷 25, 期 7, 页码 1122-1131出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2017.01.001
关键词
Intervertebral disc degeneration; Progression; Incidence; Aging; Diabetes mellitus; Longitudinal large population cohort; ROAD study; Epidemiology
资金
- Ministry of Health, Labor and Welfare [H23-Choujyu-002, H-25-Choujyu-007, H25Nanchitou (Men)-005, 201417014A, H22-Choujyu-Wakate-007]
- JSPS KAKENHI [15K15219, 26670307, 24659666, 25670293]
- Japanese Orthopedics and Traumatology Foundation, Inc. [287]
- NSF from the Ministry of Education, Culture, Sports, Science and Technology in Japan [08033011-00262]
- Japan Osteoporosis Society
- JA Kyosai Research Institute
- Mitsui Sumitomo Insurance Welfare Foundation
- Japanese Orthopaedic Association (JOA-Subsidized Science Project Research) [2006-1, 2010-2]
- [B26293139]
- [B23390172]
- [B2629333]
- [C20591774]
- [C26462249]
- [C25462305]
- [B25860448]
- [B26861286]
- [B26860419]
- [B15K20013]
- Grants-in-Aid for Scientific Research [25670293, 15K15219, 26670307, 26462249, 26293139] Funding Source: KAKEN
Objective: The present study examined the progression, incidence, and risk factors for intervertebral disc degeneration (DD) throughout the lumbar spine using magnetic resonance imaging (MRI) in a large population-based cohort. Methods: We followed up 617 subjects for more than 4 years as part of the Wakayama Spine Study. 1) Progression of DD in each of the entire, upper (L1/2 to L3/4) and lower (L4/5 and L5/S1) lumbar spine was defined as Pfirrmann grade progression at follow-up in at least one disc in the affected region. 2) Incidence of DD in each of these regions was defined if all discs were grade 3 or lower (white disc) at baseline, and at least one disc had progressed to grade 4 or higher (black disc) at follow-up. Logistic regression analyses were used to determine the risk factors for progression and incidence of DD. Results: DD progression and incidence in the entire lumbar spine were 52.0% and 31.6% in men, and 60.4% and 44.7% in women, respectively. Women was associated with DD progression in the upper lumbar spine (odds ratio [OR] = 1.68, 95% confidence interval [CI] = 1.18-2.42). Aging was associated with the incidence of DD in each region (entire: OR = 1.14, CI = 1.06-1.14; upper: OR = 1.10, CI = 1.05-1.15; lower: OR = 1.11, CI = 1.05-1.19). Diabetes mellitus (DM) was associated with the incidence of DD in the upper lumbar spine (OR = 6.83, CI = 1.07-133.7). Conclusion: This 4-year longitudinal study is the first to demonstrate DD progression and incidence in the lumbar spine and their risk factors in a large population-based cohort. (C) 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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