期刊
ORTHODONTICS & CRANIOFACIAL RESEARCH
卷 20, 期 -, 页码 100-105出版社
WILEY
DOI: 10.1111/ocr.12172
关键词
alveolar bone; orthodontic tooth movement; periodontal ligament; periodontium; Waldo method
资金
- NIH/NIDCR [R01DE022032, R00DE022059]
- NIH/NCRR [S10RR026645]
Structured Abstract ObjectiveCorrelating mechanical forces with quantifiable physical changes in the dentoalveolar complex. Setting and Sample PopulationMale 6-week C57BL/6 mice (N=3), micro X-ray-computed tomography; post-analysis software to extract physical changes in periodontal ligament (PDL)-space. Materials and MethodsSilicone-elastic bands were placed between maxillary molars for 1week, with the contralateral side as internal control. Average displacements between crowns and roots, and changes in PDL-spaces were evaluated by registering X-ray tomograms of experimental and control hemi-maxillae. Histology illustrated mineral formation and resorption-related events within narrowed and widened volumes of the PDL-space. Results3D maps of changes in PDL-space between molars illustrated coronal and root displacements of 640m and 180m, respectively, compared to 70m in controls. Orthodontic tooth movement (OTM) specimens exhibited an average net change of -20m in narrowed and +30m in widened PDL-spaces. Bone and cementum were affected by the force on molars, and primary cementum was more affected than secondary cementum. ConclusionsThis novel approach illustrates the importance of 3D-imaging and analysing 3D alveolar socket subjected to OTM otherwise omitted by 2D micrographs.A measured force on the crown elicits a response related to narrowed and widened regions in the 3D complex. OTM that exceeds PDL-space can illicit biological responses that attempt to restore physiologic PDL-space via remodelling of the periodontium. Regenerated weaker bone due to aseptic inflammation caused by orthodontics could leave patients at a higher risk of bone loss or root resorption if they later develop periodontitis, a form of septic inflammation.
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