Impact Is Important-Systematic Investigation of the Influence of Milling Balls in Mechanochemical Reactions

A newly established in situ technique using Raman Specfroscopy was employed for the detailed kinetic investigation of mechanochemical reaction pathways. This approach Was applied for the systematic investigation of the direct influence of :colliding ball's on the-reaction rate constants of a mechanochemical cocrystallization reaction. As a model reaction, the mchanochemical cocrystallizadon of felodipine and the coformer imidazole was investigated. Keeping the total ball Mass constant by varying-the number of Milling balls, our study reveals that the impact of each single collision 'has a mote significant influence on-the teaction kinetics than expected.