期刊
ORGANIC LETTERS
卷 19, 期 24, 页码 6638-6641出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03365
关键词
-
资金
- National Natural Science Foundation of China [21672037, 21532001]
A palladium-catalyzed direct C-H bond sulfonylation of indoles with the insertion of sulfur dioxide is achieved through a three-component reaction of 1-(pyridin-2-yl)indoles, DABCO.(SO2)(2), and aryldiazonium tetrafluoroborates under mild conditions. Diverse 2-sulfonated indoles are generated by using 10 mol % of palladium(II) bromide as the catalyst at room temperature. This synthetic approach is efficient by merging palladium catalysis and insertion of sulfur dioxide via a radical process. 2-Pyrimidinyl can be used as the directing group well as for the C-H bond sulfonylation. Additionally, the directing group can be easily removed.
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