期刊
ORGANIC LETTERS
卷 19, 期 10, 页码 2604-2606出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00935
关键词
-
资金
- National Natural Science Foundation of China [21572231, 21502199, 21521002]
An asymmetric transfer hydrogenation of 2,3-disubstituted quinoxalines using a chiral frustrated Lewis pair of Piers' borane and (R)-tert-butylsulfinamide as the catalyst with ammonia borane as the hydrogen source has been successfully realized. For 2-alkyl-3-arylquinoxaline substrates cis-tetrahydroquinoxalines were obtained as the predominant products in high yields with 77-86% ee. In contrast trans isomers were often furnished as major products for the reactions of 2,3-dialkylquinoxalines with up to >99% ee.
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