期刊
ORGANIC LETTERS
卷 19, 期 15, 页码 4046-4049出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01803
关键词
-
资金
- Chemical Industry Fund (FCI Liebig-fellowship)
- LMU, Munich
Alkylidenecyclobutanes (ACBs) containing all carbon quaternary stereocenters were simply and efficiently synthesized by combining boron-homologation and gamma-selective cross-coupling strategies. This unique sequence led to excellent regio- and diastereoselectivities in the generation of targeted four-membered rings with up to 99% enantiomeric excess using chiral substrates. In addition to the original synthesis of ACBs, the first asymmetric catalytic formation of quaternary stereocenters based on gamma-selective cross-coupling reactions is finally shown.
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