期刊
ORGANIC LETTERS
卷 19, 期 16, 页码 4351-4354出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02044
关键词
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资金
- NSFC [21432003, 81473095, 21602091]
- Program for Chang-jiang Scholars and Innovative Research Team in University (PCSIRT) [IRT_15R27]
- Fundamental Research Funds for the Central Universities [lzujbky-2016-ct01, lzujbky-2017-k11, lzujbky-2015-k11, lzujbky-2017-19, lzujbky-2017-118]
A magnesium catalyzed asymmetric conjugate reaction of C3-pyrrolyl-oxindoles with terminal alkynones is presented. The current asymmetric conjugate reaction relies on the development of novel combinational magnesium catalysis involving two chiral ligands. The current protocol proceeds smoothly and gives the corresponding enantioenriched 3,3-disubstituted oxindole skeletons with good enantioselectivities. Furthermore, the conjugate adducts could be transferred to spiro oixndole structures containing an eight membered ring in high ee Values.
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