期刊
ORGANIC LETTERS
卷 19, 期 9, 页码 2298-2301出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00813
关键词
-
资金
- Fundamental Research Funds for the Central Universities in China [CQDXWL-2014-Z003]
- Scientific Research Foundation of China [21402016]
- Graduate Scientific Research and Innovation Foundation of Chongqing, China [CYB16032]
A chiral, fluoride-catalyzed asymmetric cascade sulfaMichael/aldol condensation reaction of 1,4-dithiane-2,5-diol and a series of alpha,beta-unsaturated ketones is described to access chiral trisubstituted tetrahydrothiophene derivatives. The target products, including the spiro tetrahydrothiophene derivatives bearing a five-, six-, and seven-membered ring, were highly functionalized and showed high ee value. This established protocol realized a highly enantioselective reaction with a catalytic amount of KF and Song's chiral oligoEG via in situ generated chiral fluoride to construct useful heterocyclic skeletons with great complexity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据