Selenium-Iodine Cooperative Catalyst for Chlorocyclization of Tryptamine Derivatives

Chlorocyclization oftryptamine derivatives has been developed with the use of a - diphenyl diselenide-iodine cooperative catalyst. Various tryptamine derivatives can be smoothly converted to the corresponding C3a-chlorohexahydropyrrolo[233-b]indoles. Additionally, we, demonstrate the formAl total syntheses of (-)-psychotriasine and- (-)-acetylardeernin by introducing nucleophiles to the C3a poSition of the products.