期刊
ORGANIC LETTERS
卷 19, 期 20, 页码 5577-5580出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02725
关键词
-
资金
- National Natural Science Foundation of China (NNSFC) [21472190, 21532009, 21672215]
- Science Foundation of Guangdong Province, China [2014A030313796]
A palladium-catalyzed imidoylative cyclization of ethyl-3-(1H-indol-3-yl)-2-iSocyanopropanoates, derived from readily available tryptophan, to afford, beta-carboline derivatives has been developed. The reaction proceeds smoothly under mild conditions through sequential isocyanide insertion, intramolecular C-H imidoylation, and aerobic dehydrogenative aromatization with a decent substrate scope. This method provides a general approach for the synthesis of molecules containing the beta-carboline fragment.
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