Iridium-Catalyzed Enantioselective Synthesis of Dihydroimidazoquinazolinones by Elaborate Tuning of Chiral Cyclic Ligands

A highly efficient, enantio selective intramolecular allylation of (E)-4-(alkyl (4-oxo-3,4-dihydro quin azo lin-2-yl) amino) but-2-en-1-yl methyl carbonates was developed, and the corresponding dihydroimidazo-quinazolinones were prepared in high yields and enantiomeric excess. The allylation was performed under catalysis of iridium-chiral cyclic phosphoramidite complexes, in which the reactivity and enantioselectivity of the substrates were elaborately tuned by our developed chiral cyclic phosphoramidite ligands with adjustable sizes of rings.