期刊
ACS OMEGA
卷 3, 期 9, 页码 12106-12113出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.8b01513
关键词
-
资金
- Council of Scientific and Industrial Research (CSIR), New Delhi [02IJ0293)/17/EMR-I]
- National Research Foundation of South Africa [UID: 99563]
1H-1,2,3-Triazole tethered imidazole-isatin and imidazole-isatin-thiosemicarbazone conjugates were synthesized and evaluated against MCF-7 and MDA-MB-231 cell lines. Antiproliferative activities of the synthesized conjugates revealed an optimum combination of longer alkyl chain length as spacer and a halogen-substituent on the isatin ring as a prerequisite for good activity. The compound 6g with an optimum combination of chloro-substituent at C-5 position of isatin ring and a butyl chain length proved to be most active and noncytotoxic with IC50s of 54.25 and 26.12 mu M against MCF-7 and MDA-MB-231 cell lines, respectively.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据