期刊
ORGANIC LETTERS
卷 19, 期 18, 页码 4880-4883出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02339
关键词
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资金
- CAS
- High end Science and Technology Talents Program of Yunnan Province [2011HA008]
- NSFC [21472198, 21772236]
- Yunnan Province [2014FA039]
- KPTI program of Hubei Province of China [2016ACA138]
A novel strategy to construct complex poly cyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including azetidines and tropane-class alkaloids. Application of this method to naturally occurring (-)-cis-myrtanylamine, an unprecedented type of carbon-carbon bond activation, in which the electron-pair involved initiates an intramolecular S(N)2-like displacement of a cyclopalladium-fragment from a tertiary center, is described.
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